Sinusoidal obstruction syndrome (SOS) is a rare but dismal complication of high-dose chemotherapy with or without hematopoietic stem cell transplantation (HSCT), with a survival of 20% for the very severe form of the disease, despite defibrotide and modern intensive care. Data on liver transplantation for SOS in this setting are limited. The only available study is a review article gathering 20 cases, including 5 from an American transplantation database and 15 derived from 15 case reports published in the literature. This review indicates a survival rate of 40% after a median follow-up of 1.5 years. Also, a sub-analysis of the EBMT registry about solid organ transplantation associated with case reports published showed a survival rate of 33% at 1 year for liver transplant for SOS (n=18) between 1990 and 2015. The lack of solid and updated data has prevented international societies from providing a recommendation on the role of liver transplantation in SOS management.
Role of liver transplantation for sinusoidal obstruction syndrome following hematopoietic stem cell transplantation
The goal of this study is to evaluate the outcome of patients with very severe SOS following high-dose chemotherapy for a blood disease, with or without HSCT, who received or did not receive liver transplantation.
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