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I would like to add that the data on prophylactic fibrotide (quite expensive in Spain) is mainly in patients without severe choric liver disease. We are refering to a patients with BCS. A previous liver biopsy to stage the disease is very relevant, as well as other potential tools (HVPG, elastography, discarding presence of esophageal varices or oterh signs of PH) that can help to assess severity. In any case, if the hematologist finally accept to do the transplant (in our centers they usually are not prone to accept if we do not demonstarte that the liver problema is controlled and mild) I Will probably probably recommend some type of prophylaxis (although teh data is scarce and null in patients with previous liver disease).