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Appreciated these notes. I’m still finding my way through Valdig but I am finding these exchanges to be really interesting. Indeed liver disease in CVID seems to be a niche condition. I have only several of these cases but haven’t polled colleagues to see what our total might be but I suspect very small. I’ve encountered both NRH and granulomatous injury with some success in one patient with colchicine/urso combined with spreading out doses of IVIG in controlling inflammation and ascites. Do any of you have an idea of the mechanism at work? I could not pull up Dominik’s article – please check the reference. I will soon see a now retired colleague with CVID and progressive very cholestatic enzyme pattern with new onset ascites in past 3 months – relatively young woman. Thanks, Steve