Dear Audrey,
I think there is enough evidence to show that anticoagulation is safe in patients with thrombocytopenia and liver disease (mostly cirrhosis but I do not see why this should be different in your patient).
We would continue her on anticoagulation, either warfarin, LMWH, or DOAK’s (here you should not be too aggressive with the dose). I would not worry about bleeding complications, even if she would have varices. My main concern also would be the risk to develop progressive thrombosis of the splanchnic venous bed.
Kind regards,
Markus
